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however, these results should not be extrapolated to other p-gp inhibitors as colchicine is known to be a substrate for p-gp and case reports of colchicine toxicity associated with the co-administration of pgp inhibitors such as cyclosporine have been published.
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to construct a karyotype, a technician stops cell division just after the chromosomes have replicated and con- ichromosomal abnormalities densed using a chemical, such as colchicine.
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